Modeling Cardiotoxicity in Pediatric Oncology Patients Using Patient-Specific iPSC-Derived Cardiomyocytes Reveals Downregulation of Cardioprotective microRNAs

• Main Authors: Ignacio Reinal (Author), Imelda Ontoria-Oviedo (Author), Marta Selva (Author), Marilù Casini (Author), Esteban Peiró-Molina (Author), Carlos Fambuena-Santos (Author), Andreu M. Climent (Author), Julia Balaguer (Author), Adela Cañete (Author), Jaume Mora (Author), Ángel Raya (Author), Pilar Sepúlveda (Author)
• Format: Book
• Published: MDPI AG, 2023-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Anthracyclines are widely used in the treatment of many solid cancers, but their efficacy is limited by cardiotoxicity. As the number of pediatric cancer survivors continues to rise, there has been a concomitant increase in people living with anthracycline-induced cardiotoxicity. Accordingly, there...