Modeling Cardiotoxicity in Pediatric Oncology Patients Using Patient-Specific iPSC-Derived Cardiomyocytes Reveals Downregulation of Cardioprotective microRNAs

• Hoofdauteurs: Ignacio Reinal (Auteur), Imelda Ontoria-Oviedo (Auteur), Marta Selva (Auteur), Marilù Casini (Auteur), Esteban Peiró-Molina (Auteur), Carlos Fambuena-Santos (Auteur), Andreu M. Climent (Auteur), Julia Balaguer (Auteur), Adela Cañete (Auteur), Jaume Mora (Auteur), Ángel Raya (Auteur), Pilar Sepúlveda (Auteur)
• Formaat: Boek
• Gepubliceerd in: MDPI AG, 2023-07-01T00:00:00Z.
• Onderwerpen: article
• Online toegang: Connect to this object online.

Anthracyclines are widely used in the treatment of many solid cancers, but their efficacy is limited by cardiotoxicity. As the number of pediatric cancer survivors continues to rise, there has been a concomitant increase in people living with anthracycline-induced cardiotoxicity. Accordingly, there...