Modeling Cardiotoxicity in Pediatric Oncology Patients Using Patient-Specific iPSC-Derived Cardiomyocytes Reveals Downregulation of Cardioprotective microRNAs
Anthracyclines are widely used in the treatment of many solid cancers, but their efficacy is limited by cardiotoxicity. As the number of pediatric cancer survivors continues to rise, there has been a concomitant increase in people living with anthracycline-induced cardiotoxicity. Accordingly, there...
Saved in:
Main Authors: | Ignacio Reinal (Author), Imelda Ontoria-Oviedo (Author), Marta Selva (Author), Marilù Casini (Author), Esteban Peiró-Molina (Author), Carlos Fambuena-Santos (Author), Andreu M. Climent (Author), Julia Balaguer (Author), Adela Cañete (Author), Jaume Mora (Author), Ángel Raya (Author), Pilar Sepúlveda (Author) |
---|---|
Format: | Book |
Published: |
MDPI AG,
2023-07-01T00:00:00Z.
|
Subjects: | |
Online Access: | Connect to this object online. |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Similar Items
-
iPSC-cardiomyocytes in the preclinical prediction of candidate pharmaceutical toxicity
by: Tim Y. T. Lee, et al.
Published: (2024) -
Unchain My Heart: Integrins at the Basis of iPSC Cardiomyocyte Differentiation
by: Rosaria Santoro, et al.
Published: (2019) -
Evaluation of MYBPC3 trans-Splicing and Gene Replacement as Therapeutic Options in Human iPSC-Derived Cardiomyocytes
by: Maksymilian Prondzynski, et al.
Published: (2017) -
Hapln1 promotes dedifferentiation and proliferation of iPSC-derived cardiomyocytes by promoting versican-based GDF11 trapping
by: Ding-Jun Hao, et al.
Published: (2024) -
Spontaneous recovery from sunitinib-induced disruption of sarcomere in human iPSC-cardiomyocytes and possible involvement of the Hippo pathway
by: Toshikatsu Matsui, et al.
Published: (2021)