Risk assessment of drug-drug interaction potential for bintrafusp alfa with cytochrome P4503A4 substrates: A totality of evidence approach

Abstract Bintrafusp alfa, a first‐in‐class bifunctional fusion protein composed of the extracellular domain of TGF‐βRII (a TGF‐β "trap") fused to a human IgG1 mAb blocking PD‐L1, is being evaluated for efficacy and safety in solid tumor indications as monotherapy and in combination with sm...

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Bibliographic Details
Main Authors: Yulia Vugmeyster (Author), George Locke (Author), Christoph Helwig (Author), P. Alexander Rolfe (Author), Jennifer Q. Dong (Author), Karthik Venkatakrishnan (Author)
Format: Book
Published: Wiley, 2022-12-01T00:00:00Z.
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3rd Floor Main Library

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Call Number: A1234.567
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