Risk assessment of drug-drug interaction potential for bintrafusp alfa with cytochrome P4503A4 substrates: A totality of evidence approach

• Asıl Yazarlar: Yulia Vugmeyster (Yazar), George Locke (Yazar), Christoph Helwig (Yazar), P. Alexander Rolfe (Yazar), Jennifer Q. Dong (Yazar), Karthik Venkatakrishnan (Yazar)
• Materyal Türü: Kitap
• Baskı/Yayın Bilgisi: Wiley, 2022-12-01T00:00:00Z.
• Konular: article
• Online Erişim: Connect to this object online.

Abstract Bintrafusp alfa, a first‐in‐class bifunctional fusion protein composed of the extracellular domain of TGF‐βRII (a TGF‐β "trap") fused to a human IgG1 mAb blocking PD‐L1, is being evaluated for efficacy and safety in solid tumor indications as monotherapy and in combination with sm...