Correction of cognitive deficits in mouse models of Down syndrome by a pharmacological inhibitor of DYRK1A

• Main Authors: Thu Lan Nguyen (Author), Arnaud Duchon (Author), Antigoni Manousopoulou (Author), Nadège Loaëc (Author), Benoît Villiers (Author), Guillaume Pani (Author), Meltem Karatas (Author), Anna E. Mechling (Author), Laura-Adela Harsan (Author), Emmanuelle Limanton (Author), Jean-Pierre Bazureau (Author), François Carreaux (Author), Spiros D. Garbis (Author), Laurent Meijer (Author), Yann Herault (Author)
• Format: Book
• Published: The Company of Biologists, 2018-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Growing evidence supports the implication of DYRK1A in the development of cognitive deficits seen in Down syndrome (DS) and Alzheimer's disease (AD). We here demonstrate that pharmacological inhibition of brain DYRK1A is able to correct recognition memory deficits in three DS mouse models with...