A cheminformatics and network pharmacology approach to elucidate the mechanism of action of Mycobacterium tuberculosis γ-carbonic anhydrase inhibitors

• Main Authors: Ajay Manaithiya (Author), Ratul Bhowmik (Author), Kunal Bhattacharya (Author), Rajarshi Ray (Author), Sagar Singh Shyamal (Author), Fabrizio Carta (Author), Claudiu T. Supuran (Author), Seppo Parkkila (Author), Ashok Aspatwar (Author)
• Format: Book
• Published: Frontiers Media S.A., 2024-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

BackgroundMycobacterium tuberculosis (Mtb) carbonic anhydrases (CAs) are critical enzymes that regulate pH by converting CO2 to HCO3−, essential for Mtb's survival in acidic environments. Inhibiting γ-CAs presents a potential target for novel antituberculosis drugs with unique mechanisms of act...