Identification of PCSK9-like human gene knockouts using metabolomics, proteomics, and whole-genome sequencing in a consanguineous population

• Prif Awduron: Aziz Belkadi (Awdur), Gaurav Thareja (Awdur), Fatemeh Abbaszadeh (Awdur), Ramin Badii (Awdur), Eric Fauman (Awdur), Omar M.E. Albagha (Awdur), Karsten Suhre (Awdur)
• Fformat: Llyfr
• Cyhoeddwyd: Elsevier, 2023-01-01T00:00:00Z.
• Pynciau: article
• Mynediad Ar-lein: Connect to this object online.

Summary: Natural human knockouts of genes associated with desirable outcomes, such as PCSK9 with low levels of LDL-cholesterol, can lead to the discovery of new drug targets and treatments. Rare loss-of-function variants are more likely to be found in the homozygous state in consanguineous populatio...