Identification of PCSK9-like human gene knockouts using metabolomics, proteomics, and whole-genome sequencing in a consanguineous population

• Main Authors: Aziz Belkadi (Author), Gaurav Thareja (Author), Fatemeh Abbaszadeh (Author), Ramin Badii (Author), Eric Fauman (Author), Omar M.E. Albagha (Author), Karsten Suhre (Author)
• Format: Book
• Published: Elsevier, 2023-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Summary: Natural human knockouts of genes associated with desirable outcomes, such as PCSK9 with low levels of LDL-cholesterol, can lead to the discovery of new drug targets and treatments. Rare loss-of-function variants are more likely to be found in the homozygous state in consanguineous populatio...