Identification of PCSK9-like human gene knockouts using metabolomics, proteomics, and whole-genome sequencing in a consanguineous population
Summary: Natural human knockouts of genes associated with desirable outcomes, such as PCSK9 with low levels of LDL-cholesterol, can lead to the discovery of new drug targets and treatments. Rare loss-of-function variants are more likely to be found in the homozygous state in consanguineous populatio...
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| Main Authors: | , , , , , , |
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| Format: | Book |
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Elsevier,
2023-01-01T00:00:00Z.
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| Online Access: | Connect to this object online. |
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