Quantitative single-cell analysis of Leishmania major amastigote differentiation demonstrates variably extended expression of the lipophosphoglycan (LPG) virulence factor in different host cell types.

• Prif Awduron: Michael A Mandell (Awdur), Wandy L Beatty (Awdur), Stephen M Beverley (Awdur)
• Fformat: Llyfr
• Cyhoeddwyd: Public Library of Science (PLoS), 2022-10-01T00:00:00Z.
• Pynciau: article
• Mynediad Ar-lein: Connect to this object online.

Immediately following their deposition into the mammalian host by an infected sand fly vector, Leishmania parasites encounter and are engulfed by a variety of cell types. From there, parasites may transit to other cell types, primarily macrophages or dendritic cells, where they replicate and induce...