A novel and low-toxic peptide DR3penA alleviates pulmonary fibrosis by regulating the MAPK/miR-23b-5p/AQP5 signaling axis

• Main Authors: Dan Wang (Author), Bochuan Deng (Author), Lu Cheng (Author), Jieru Li (Author), Jiao Zhang (Author), Xiang Zhang (Author), Xiaomin Guo (Author), Tiantian Yan (Author), Xin Yue (Author), Yingying An (Author), Bangzhi Zhang (Author), Wenle Yang (Author), Junqiu Xie (Author), Rui Wang (Author)
• Format: Book
• Published: Elsevier, 2023-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Pulmonary fibrosis (PF) is a pathological change caused by repeated injuries and repair dysfunction of the alveolar epithelium. Our previous study revealed that the residues Asn3 and Asn4 of peptide DR8 (DHNNPQIR-NH2) could be modified to improve stability and antifibrotic activity, and the unnatura...