Comparative analysis activation of post-receptor signal ways by dimeric dipeptide mimetiks of different loops of NGF
On culture of hippocampal HT-22 cells line it is shown that dimeric dipeptide mimetiks of different Loops of NGF realize their action via specific neurotrophic TrkA-receptor and selective activate post-receptor intracellular signal ways. Mimetiks of 1th (GK-6 (10-6M)) and the 3rd Loops (GTS-115 ((10...
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2016-03-01T00:00:00Z.
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|---|---|---|---|
| 001 | doaj_e196399e3ccb4e7e86fdadb54fb902b5 | ||
| 042 | |a dc | ||
| 100 | 1 | 0 | |a T. A. Antipova |e author |
| 700 | 1 | 0 | |a I. O. Logvinov |e author |
| 700 | 1 | 0 | |a S. V. Nikolaev |e author |
| 700 | 1 | 0 | |a S. V. Kruglov |e author |
| 700 | 1 | 0 | |a A. V. Tarasiuk |e author |
| 700 | 1 | 0 | |a P. I. Antipov |e author |
| 700 | 1 | 0 | |a T. A. Gudasheva |e author |
| 700 | 1 | 0 | |a S. B. Seredenin |e author |
| 245 | 0 | 0 | |a Comparative analysis activation of post-receptor signal ways by dimeric dipeptide mimetiks of different loops of NGF |
| 260 | |b LLC "Publisher OKI", |c 2016-03-01T00:00:00Z. | ||
| 500 | |a 2587-7836 | ||
| 500 | |a 2686-8830 | ||
| 520 | |a On culture of hippocampal HT-22 cells line it is shown that dimeric dipeptide mimetiks of different Loops of NGF realize their action via specific neurotrophic TrkA-receptor and selective activate post-receptor intracellular signal ways. Mimetiks of 1th (GK-6 (10-6M)) and the 3rd Loops (GTS-115 ((10-6M)) evoke activation of two main signal cascades - PI3/Akt and MAP/Erk, while mimetic the 4th loop of NGF (GK-2 (10-8M)) only one - a PI3/Akt-way. | ||
| 546 | |a RU | ||
| 690 | |a ngf | ||
| 690 | |a trk-a | ||
| 690 | |a внутриклеточный сигналинг | ||
| 690 | |a димерные дипептидные миметики | ||
| 690 | |a ngf | ||
| 690 | |a trk-a | ||
| 690 | |a intracellular signaling | ||
| 690 | |a dimeric dipeptide mimetiks | ||
| 690 | |a Pharmacy and materia medica | ||
| 690 | |a RS1-441 | ||
| 655 | 7 | |a article |2 local | |
| 786 | 0 | |n Фармакокинетика и Фармакодинамика, Vol 0, Iss 2, Pp 14-17 (2016) | |
| 787 | 0 | |n https://www.pharmacokinetica.ru/jour/article/view/168 | |
| 787 | 0 | |n https://doaj.org/toc/2587-7836 | |
| 787 | 0 | |n https://doaj.org/toc/2686-8830 | |
| 856 | 4 | 1 | |u https://doaj.org/article/e196399e3ccb4e7e86fdadb54fb902b5 |z Connect to this object online. |