Electroporation Enhanced Effect of Dystrophin Splice Switching PNA Oligomers in Normal and Dystrophic Muscle

• Egile Nagusiak: Camilla Brolin (Egilea), Takehiko Shiraishi (Egilea), Pernille Hojman (Egilea), Thomas O Krag (Egilea), Peter E Nielsen (Egilea), Julie Gehl (Egilea)
• Formatua: Liburua
• Argitaratua: Elsevier, 2015-01-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

Peptide nucleic acid (PNA) is a synthetic DNA mimic that has shown potential for discovery of novel splice switching antisense drugs. However, in vivo cellular delivery has been a limiting factor for development, and only few successful studies have been reported. As a possible modality for improvem...