The Effect of Simvastatin on Gut Microbiota and Lipid Metabolism in Hyperlipidemic Rats Induced by a High-Fat Diet

• Main Authors: Qing Zhang (Author), Xiaoyun Fan (Author), Rui Ye (Author), Yuzhong Hu (Author), Tingting Zheng (Author), Rui Shi (Author), Wenjian Cheng (Author), Xucong Lv (Author), Lijiao Chen (Author), Peng Liang (Author)
• Format: Book
• Published: Frontiers Media S.A., 2020-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The objective of this study was to investigate the effects of simvastatin (SIM) on lipid metabolism disorders and gut microbiota in high-fat diet-induced hyperlipidemic rats. The obtained results revealed that feeding rats with SIM (20 mg/kg/day) significantly decreased serum lipid level and inhibit...