Myeloid HIF-1 attenuates the progression of renal fibrosis in murine obstructive nephropathy

• Main Authors: Yu Tateishi (Author), Mayuko Osada-Oka (Author), Masako Tanaka (Author), Masayuki Shiota (Author), Yasukatsu Izumi (Author), Eiji Ishimura (Author), Koka Motoyama (Author), Masaaki Inaba (Author), Katsuyuki Miura (Author)
• Format: Book
• Published: Elsevier, 2015-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Hypoxia-inducible factors (HIFs) play an important role in the pathogenesis of renal fibrosis. Although the role of macrophage infiltration in the progression of renal fibrosis is well known, the role of macrophage HIF-1 remains to be revealed. To address this question, myeloid specific conditional...