Targets Fishing and Identification of Calenduloside E as Hsp90AB1: Design, Synthesis, and Evaluation of Clickable Activity-Based Probe

• Main Authors: Shan Wang (Author), Yu Tian (Author), Jing-Yi Zhang (Author), Hui-Bo Xu (Author), Ping Zhou (Author), Min Wang (Author), Sen-Bao Lu (Author), Yun Luo (Author), Gui-Bo Sun (Author), Xu-Dong Xu (Author), Xiao-Bo Sun (Author)
• Format: Book
• Published: Frontiers Media S.A., 2018-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Calenduloside E (CE), a natural triterpenoid compound isolated from Aralia elata, can protect against ox-LDL-induced human umbilical vein endothelial cell (HUVEC) injury in our previous reports. However, the exact targets and mechanisms of CE remain elusive. For the sake of resolving this question,...