Heavy chain-only antibodies with a stabilized human VH in transgenic chickens for therapeutic antibody discovery

• Prif Awduron: Christine N. Vuong (Awdur), Kevin M. Reynolds (Awdur), Gerry S. Rivera (Awdur), Baisen Zeng (Awdur), Zahra Karimpourkalou (Awdur), Manith Norng (Awdur), Yulei Zhang (Awdur), Robayet Chowdhury (Awdur), Darlene Pedersen (Awdur), Melissa Pantoja (Awdur), Ellen Collarini (Awdur), Swetha Garimalla (Awdur), Shelley Izquierdo (Awdur), Eric G. Vajda (Awdur), Brett Antonio (Awdur), Devendra B. Srivastava (Awdur), Marie-Cecile van de Lavoir (Awdur), Yasmina Abdiche (Awdur), William Harriman (Awdur), Philip A. Leighton (Awdur)
• Fformat: Llyfr
• Cyhoeddwyd: Taylor & Francis Group, 2024-12-01T00:00:00Z.
• Pynciau: article
• Mynediad Ar-lein: Connect to this object online.

Heavy chain-only antibodies have found many applications where conventional heavy-light heterodimeric antibodies are not favorable. Heavy chain-only antibodies with their single antigen-binding domain offer the advantage of a smaller size and higher stability relative to conventional antibodies, and...