Rapid, simple, and clinically applicable high-performance liquid chromatography method for clinical determination of plasma colistin concentrations

• Main Authors: Yuki Hanai (Author), Kazuhiro Matsuo (Author), Takayoshi Kosugi (Author), Ayumu Kusano (Author), Hayato Ohashi (Author), Itsuki Kimura (Author), Shinobu Hirayama (Author), Yuta Nanjo (Author), Yoshikazu Ishii (Author), Takahiro Sato (Author), Taito Miyazaki (Author), Kenji Nishizawa (Author), Takashi Yoshio (Author)
• Format: Book
• Published: BMC, 2018-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Since both the antibacterial effects and common adverse effects of colistin are concentration-dependent, determination of the most appropriate dosage regimen and administration method for colistin therapy is essential to ensure its efficacy and safety. We aimed to establish a rap...