Effect of Apixaban Pretreatment on Alteplase-Induced Thrombolysis: An In Vitro Study

• Main Authors: Sandra Thalerová (Author), Michaela Pešková (Author), Patrícia Kittová (Author), Sumeet Gulati (Author), Jan Víteček (Author), Lukáš Kubala (Author), Robert Mikulík (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Benefit of thrombolytic therapy in patients with acute stroke, who are on anticoagulant treatment, is not well addressed. The aim of this study was to investigate whether apixaban can modify the thrombolytic efficacy of alteplase in vitro. Static and flow models and two variants of red blood cell (R...