Midkine Is a Novel Regulator of Amphetamine-Induced Striatal Gliosis and Cognitive Impairment: Evidence for a Stimulus-Dependent Regulation of Neuroinflammation by Midkine

• Päätekijät: Marta Vicente-Rodríguez (Tekijä), Rosalía Fernández-Calle (Tekijä), Esther Gramage (Tekijä), Carmen Pérez-García (Tekijä), María P. Ramos (Tekijä), Gonzalo Herradón (Tekijä)
• Aineistotyyppi: Kirja
• Julkaistu: Hindawi Limited, 2016-01-01T00:00:00Z.
• Aiheet: article
• Linkit: Connect to this object online.

Midkine (MK) is a cytokine that modulates amphetamine-induced striatal astrogliosis, suggesting a possible role of MK in neuroinflammation induced by amphetamine. To test this hypothesis, we studied astrogliosis and microglial response induced by amphetamine (10 mg/kg i.p. four times, every 2 h) in...