The NF-κB specific inhibitor DHMEQ prevents thrombus formation in a mouse model of antiphospholipid syndrome

• Main Authors: Misato Nishimura (Author), Tokiko Nii (Author), Gulzhan Trimova (Author), Shuhei Miura (Author), Kazuo Umezawa (Author), Akira Ushiyama (Author), Tetsuo Kubota (Author)
• Format: Book
• Published: Society of Diabetic Nephropathy Prevention, 2013-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: β2-glycoprotein I (β2GPI)-dependent antiphospholipid antibodies (aPLs) are considered to play a pivotal pathogenic role in antiphospholipid syndrome (APS) by inducing the expression of tissue factor, inflammatory cytokines, and chemokines, most of which are dependent upon the NF-κB pathw...