FTD/ALS Type 7-Associated Thr104Asn Mutation of CHMP2B Blunts Neuronal Process Elongation, and Is Recovered by Knockdown of Arf4, the Golgi Stress Regulator

• Main Authors: Remina Shirai (Author), Mizuka Cho (Author), Mikinori Isogai (Author), Shoya Fukatsu (Author), Miyu Okabe (Author), Maho Okawa (Author), Yuki Miyamoto (Author), Tomohiro Torii (Author), Junji Yamauchi (Author)
• Format: Book
• Published: MDPI AG, 2023-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Frontotemporal dementia and/or amyotrophic lateral sclerosis type 7 (FTD/ALS7) is an autosomal dominant neurodegenerative disorder characterized by the onset of FTD and/or ALS, mainly in adulthood. Patients with some types of mutations, including the Thr104Asn (T104N) mutation of charged multivesicu...