Efficient Synthesis of 2,3'-Spirobi (Indolin)-2'-Ones and Preliminary Evaluation of Their Damage to Mitochondria in HeLa Cells

• Main Authors: Huajie Li (Author), Zhenjie Yu (Author), Haoyi Sun (Author), Bo Liu (Author), Xin Wang (Author), Zhe Shao (Author), Meiling Wang (Author), Weilin Xie (Author), Xingang Yao (Author), Qingqiang Yao (Author), Ying Zhi (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

A novel formal (4 + 1) annulation between N-(o-chloromethyl)aryl amides and 3-chlorooxindoles through in situ generated aza-ortho-QMs with 3-chlorooxindoles is reported for the synthesis of a series of 2,3'-spirobi (indolin)-2'-ones in high yields. Under structured illumination microscopy,...