Plasma exosomes from children with juvenile dermatomyositis are taken up by human aortic endothelial cells and are associated with altered gene expression in those cells

• Main Authors: Kaiyu Jiang (Author), Rie Karasawa (Author), Zihua Hu (Author), Yanmin Chen (Author), Lucy Holmes (Author), Kathleen M. O'Neil (Author), James N. Jarvis (Author)
• Format: Book
• Published: BMC, 2019-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background The pathology of juvenile dermatomyositis (JDM) is characterized by prominent vessel wall and perivascular inflammation. This feature of the disease has remained unexplained and under-investigated. We have hypothesized that plasma exosomes, which play an important role in inter-c...