Renal failure suppresses muscle irisin expression, and irisin blunts cortical bone loss in mice

• Main Authors: Naoyuki Kawao (Author), Miku Kawaguchi (Author), Takashi Ohira (Author), Hiroki Ehara (Author), Yuya Mizukami (Author), Yoshimasa Takafuji (Author), Hiroshi Kaji (Author)
• Format: Book
• Published: Wiley, 2022-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Chronic renal failure induces bone mineral disorders and sarcopenia. Skeletal muscle affects other tissues, including bone, by releasing myokines. However, the effects of chronic renal failure on the interactions between muscle and bone remain unclear. Methods We investigated the...