Ion-dependent slow protein release from in vivo disintegrating micro-granules

• Egile Nagusiak: Patricia Álamo (Egilea), Eloi Parladé (Egilea), Hèctor López-Laguna (Egilea), Eric Voltà-Durán (Egilea), Ugutz Unzueta (Egilea), Esther Vazquez (Egilea), Ramon Mangues (Egilea), Antonio Villaverde (Egilea)
• Formatua: Liburua
• Argitaratua: Taylor & Francis Group, 2021-01-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

Through the controlled addition of divalent cations, polyhistidine-tagged proteins can be clustered in form of chemically pure and mechanically stable micron-scale particles. Under physiological conditions, these materials act as self-disintegrating protein depots for the progressive release of the...