Ion-dependent slow protein release from in vivo disintegrating micro-granules

• Main Authors: Patricia Álamo (Author), Eloi Parladé (Author), Hèctor López-Laguna (Author), Eric Voltà-Durán (Author), Ugutz Unzueta (Author), Esther Vazquez (Author), Ramon Mangues (Author), Antonio Villaverde (Author)
• Format: Book
• Published: Taylor & Francis Group, 2021-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Through the controlled addition of divalent cations, polyhistidine-tagged proteins can be clustered in form of chemically pure and mechanically stable micron-scale particles. Under physiological conditions, these materials act as self-disintegrating protein depots for the progressive release of the...