Guiding the starting dose of the once-daily formulation of tacrolimus in "de novo" adult renal transplant patients: a population approach

• Main Authors: Beatriz Fernández-Alarcón (Author), Oscar Nolberger (Author), Anna Vidal-Alabró (Author), Raul Rigo-Bonnin (Author), Josep M. Grinyó (Author), Edoardo Melilli (Author), Nuria Montero (Author), Anna Manonelles (Author), Ana Coloma (Author), Alex Favà (Author), Sergi Codina (Author), Josep M. Cruzado (Author), Helena Colom (Author), Nuria Lloberas (Author)
• Format: Book
• Published: Frontiers Media S.A., 2024-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

AimsThe once-daily extended-release tacrolimus formulation (ER-Tac) has demonstrated similar efficacy and safety to the twice-daily immediate-release formulation (IR-Tac), but few population-based pharmacokinetic models have been developed in de novo kidney transplant patients to optimize doses. The...