Discovery of curcumin inspired sulfonamide derivatives as a new class of carbonic anhydrase isoforms I, II, IX, and XII inhibitors

• Main Authors: P. V. Sri Ramya (Author), Srinivas Angapelly (Author), Andrea Angeli (Author), Chander Singh Digwal (Author), Mohammed Arifuddin (Author), Bathini Nagendra Babu (Author), Claudiu T. Supuran (Author), Ahmed Kamal (Author)
• Format: Book
• Published: Taylor & Francis Group, 2017-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

A series of curcumin inspired sulfonamide derivatives was prepared from various chalcones and 4-sulfamoyl benzaldehyde via Claisen-Schmidt condensation. All new compounds were assayed as inhibitors of four human isoforms of the metalloenzyme carbonic anhydrase (hCA, EC 4.2.1.1) isoforms hCA I, II, I...