Discovery of curcumin inspired sulfonamide derivatives as a new class of carbonic anhydrase isoforms I, II, IX, and XII inhibitors

A series of curcumin inspired sulfonamide derivatives was prepared from various chalcones and 4-sulfamoyl benzaldehyde via Claisen-Schmidt condensation. All new compounds were assayed as inhibitors of four human isoforms of the metalloenzyme carbonic anhydrase (hCA, EC 4.2.1.1) isoforms hCA I, II, I...

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Principais autores: P. V. Sri Ramya (Autor), Srinivas Angapelly (Autor), Andrea Angeli (Autor), Chander Singh Digwal (Autor), Mohammed Arifuddin (Autor), Bathini Nagendra Babu (Autor), Claudiu T. Supuran (Autor), Ahmed Kamal (Autor)
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Publicado em: Taylor & Francis Group, 2017-01-01T00:00:00Z.
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3rd Floor Main Library

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