Tisagenlecleucel Model‐Based Cellular Kinetic Analysis of Chimeric Antigen Receptor-T Cells

• Main Authors: Andrew M. Stein (Author), Stephan A. Grupp (Author), John E. Levine (Author), Theodore W. Laetsch (Author), Michael A. Pulsipher (Author), Michael W. Boyer (Author), Keith J. August (Author), Bruce L. Levine (Author), Lori Tomassian (Author), Sweta Shah (Author), Mimi Leung (Author), Pai‐Hsi Huang (Author), Rakesh Awasthi (Author), Karen Thudium Mueller (Author), Patricia A. Wood (Author), Carl H. June (Author)
• Format: Book
• Published: Wiley, 2019-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Tisagenlecleucel is a chimeric antigen receptor-T cell therapy that facilitates the killing of CD19+ B cells. A model was developed for the kinetics of tisagenlecleucel and the impact of therapies for treating cytokine release syndrome (tocilizumab and corticosteroids) on expansion. Data from two ph...