Kinome-Wide siRNA Screening Identifies Src-Enhanced Resistance of Chemotherapeutic Drugs in Triple-Negative Breast Cancer Cells

• Main Authors: Yen-Dun Tony Tzeng (Author), Pei-Feng Liu (Author), Ju-Yueh Li (Author), Li-Feng Liu (Author), Soong-Yu Kuo (Author), Chiao-Wei Hsieh (Author), Cheng-Hsin Lee (Author), Chih-Hsuan Wu (Author), Michael Hsiao (Author), Hong-Tai Chang (Author), Chih-Wen Shu (Author)
• Format: Book
• Published: Frontiers Media S.A., 2018-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: Chemotherapy is the main treatment for triple-negative breast cancer (TNBC), which lack molecular markers for diagnosis and therapy. Cancer cells activate chemoresistant pathways and lead to therapeutic failure for patients with TNBC. Several kinases have been identified as chemoresistan...