Combination of protein and cell internalization SELEX identifies a potential RNA therapeutic and delivery platform to treat EphA2-expressing tumors

• Main Authors: Laura Santana-Viera (Author), Justin P. Dassie (Author), Marta Rosàs-Lapeña (Author), Silvia Garcia-Monclús (Author), Mariona Chicón-Bosch (Author), Marina Pérez-Capó (Author), Lidia del Pozo (Author), Sara Sanchez-Serra (Author), Olga Almacellas-Rabaiget (Author), Susana Maqueda-Marcos (Author), Roser López-Alemany (Author), William H. Thiel (Author), Paloma H. Giangrande (Author), Oscar M. Tirado (Author)
• Format: Book
• Published: Elsevier, 2023-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The EphA2 receptor tyrosine kinase is overexpressed in most solid tumors and acts as the major driver of tumorigenesis. In this study, we developed a novel approach for targeting the EphA2 receptor using a 2'-fluoro-modified pyrimidine RNA aptamer termed ATOP. We identified the ATOP EphA2 aptam...