Observation of high-temperature macromolecular confinement in lyophilised protein formulations using terahertz spectroscopy

• Main Authors: Talia A. Shmool (Author), P.J. Woodhams (Author), Markus Leutzsch (Author), Amberley D. Stephens (Author), Mario U. Gaimann (Author), Michael D. Mantle (Author), Gabriele S. Kaminski Schierle (Author), Christopher F. van der Walle (Author), J. Axel Zeitler (Author)
• Format: Book
• Published: Elsevier, 2019-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Characterising the structural dynamics of proteins and the effects of excipients are critical for optimising the design of formulations. In this work we investigated four lyophilised formulations containing bovine serum albumin (BSA) and three formulations containing a monoclonal antibody (mAb, here...