Impact of global PTP1B deficiency on the gut barrier permeability during NASH in mice

• Main Authors: Carmen Rubio (Author), Marta Puerto (Author), Juan J. García-Rodríquez (Author), Van B. Lu (Author), Irma García-Martínez (Author), Rosa Alén (Author), Patricia Sanmartín-Salinas (Author), M. Val Toledo-Lobo (Author), Jorge Saiz (Author), Javier Ruperez (Author), Coral Barbas (Author), Luis Menchén (Author), Fiona M. Gribble (Author), Frank Reimann (Author), Luis G. Guijarro (Author), Jose M. Carrascosa (Author), Ángela M. Valverde (Author)
• Format: Book
• Published: Elsevier, 2020-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Non-alcoholic steatohepatitis (NASH) is characterized by a robust pro-inflammatory component at both hepatic and systemic levels together with a disease-specific gut microbiome signature. Protein tyrosine phosphatase 1 B (PTP1B) plays distinct roles in non-immune and immune cells, in the...