ICG-001, an Inhibitor of the β-Catenin and cAMP Response Element-Binding Protein Dependent Gene Transcription, Decreases Proliferation but Enhances Migration of Osteosarcoma Cells

• Main Authors: Geoffroy Danieau (Author), Sarah Morice (Author), Sarah Renault (Author), Régis Brion (Author), Kevin Biteau (Author), Jérôme Amiaud (Author), Marie Cadé (Author), Dominique Heymann (Author), Frédéric Lézot (Author), Franck Verrecchia (Author), Françoise Rédini (Author), Bénédicte Brounais-Le Royer (Author)
• Format: Book
• Published: MDPI AG, 2021-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

High-grade osteosarcomas are the most frequent malignant bone tumors in the pediatric population, with 150 patients diagnosed every year in France. Osteosarcomas are associated with low survival rates for high risk patients (metastatic and relapsed diseases). Knowing that the canonical Wnt signaling...