Improvement of ACK1-targeted therapy efficacy in lung adenocarcinoma using chloroquine or bafilomycin A1

• Main Authors: Jinhong Zhu (Author), Kui Cao (Author), Meng Zhao (Author), Keru Ma (Author), Xiangyu Jiang (Author), Yuwen Bai (Author), Xiaodong Ling (Author), Jianqun Ma (Author)
• Format: Book
• Published: BMC, 2023-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Activated Cdc42-associated kinase 1 (ACK1) is a promising druggable target for cancer, but its inhibitors only showed moderate effects in clinical trials. The study aimed to investigate the underlying mechanisms and improve the antitumor efficacy of ACK1 inhibitors. Methods RNA-s...