Puerarin Suppresses Angiotensin II-Induced Cardiac Hypertrophy by Inhibiting NADPH Oxidase Activation and Oxidative Stress-Triggered AP-1 Signaling Pathways

• Main Authors: Chen Gang (Author), Cao Qiang (Author), Cui Xiangli (Author), Pan Shifen (Author), Shen Chong (Author), Liu Lihong (Author)
• Format: Book
• Published: Frontiers Media S.A., 2015-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

PURPOSE. To examine the effects of puerarin (Pue) on angiotensin II (AngII)-induced nicotinamide adenine dinucleotide phosphate (NADPH) oxidase activation and oxidative stress-related signaling pathways in the hypertrophic response of cardiomyocytes. METHODS. Primary cardiomyocytes of neonatal C57BL...