Mechanistic Insights into Binding of Ligands with Thiazolidinedione Warhead to Human Histone Deacetylase 4

Mechanistic Insights into Binding of Ligands with Thiazolidinedione Warhead to Human Histone Deacetylase 4

Recently, we have reported that non-hydroxamate thiazolidinedione (TZD) analogs are capable of inhibiting human deacetylase 4 (HDAC4). This study aims at the dissection of the molecular determinants and kinetics of the molecular recognition of TZD ligands by HDAC4. For this purpose, a structure acti...

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Main Authors: Markus Schweipert (Author), Niklas Jänsch (Author), Neha Upadhyay (Author), Kalpana Tilekar (Author), Ewelina Wozny (Author), Sidra Basheer (Author), Eva Wurster (Author), Marlene Müller (Author), Ramaa C S (Author), Franz-Josef (Author)
Format: Book
Published: MDPI AG, 2021-10-01T00:00:00Z.
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3rd Floor Main Library

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