Macrophages are essential for CTGF-mediated adult β-cell proliferation after injury

• Main Authors: Kimberly G. Riley (Author), Raymond C. Pasek (Author), Matthew F. Maulis (Author), Jennifer C. Dunn (Author), W. Reid Bolus (Author), Peggy L. Kendall (Author), Alyssa H. Hasty (Author), Maureen Gannon (Author)
• Format: Book
• Published: Elsevier, 2015-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Promotion of endogenous β-cell mass expansion could facilitate regeneration in patients with diabetes. We discovered that the secreted protein CTGF (aka CCN2) promotes adult β-cell replication and mass regeneration after injury via increasing β-cell immaturity and shortening the replicati...