The miR-200-Zeb1 axis regulates key aspects of β-cell function and survival in vivo

• Main Authors: Alexandra C. Title (Author), Pamuditha N. Silva (Author), Svenja Godbersen (Author), Lynn Hasenöhrl (Author), Markus Stoffel (Author)
• Format: Book
• Published: Elsevier, 2021-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: The miR-200-Zeb1 axis regulates the epithelial-to-mesenchymal transition (EMT), differentiation, and resistance to apoptosis. A better understanding of these processes in diabetes is highly relevant, as β-cell dedifferentiation and apoptosis contribute to the loss of functional β-cell mas...