Suppression of insulin-induced gene 1 (INSIG1) function promotes hepatic lipid remodelling and restrains NASH progression

• Main Authors: Vian Azzu (Author), Michele Vacca (Author), Ioannis Kamzolas (Author), Zoe Hall (Author), Jack Leslie (Author), Stefania Carobbio (Author), Samuel Virtue (Author), Susan E. Davies (Author), Agnes Lukasik (Author), Martin Dale (Author), Mohammad Bohlooly-Y (Author), Animesh Acharjee (Author), Daniel Lindén (Author), Guillaume Bidault (Author), Evangelia Petsalaki (Author), Julian L. Griffin (Author), Fiona Oakley (Author), Michael E.D. Allison (Author), Antonio Vidal-Puig (Author)
• Format: Book
• Published: Elsevier, 2021-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Non-alcoholic fatty liver disease (NAFLD) is a silent pandemic associated with obesity and the metabolic syndrome, and also increases cardiovascular- and cirrhosis-related morbidity and mortality. A complete understanding of adaptive compensatory metabolic programmes that modulate non-alc...