Fisetin Inhibits Osteoclastogenesis Through Prevention of RANKL-Induced ROS Production by Nrf2-Mediated Up-regulation of Phase II Antioxidant Enzymes

• Main Authors: Eiko Sakai (Author), Megumi Shimada-Sugawara (Author), Yu Yamaguchi (Author), Hiroshi Sakamoto (Author), Reiko Fumimoto (Author), Yutaka Fukuma (Author), Kazuhisa Nishishita (Author), Kuniaki Okamoto (Author), Takayuki Tsukuba (Author)
• Format: Book
• Published: Elsevier, 2013-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract.: Osteoclasts (OCLs) are multinucleated bone-resorbing cells that are differentiated by stimulation with receptor activator of nuclear factor kappa-B ligand (RANKL) and macrophage colony-stimulating factor. We recently demonstrated that regulation of heme-oxygenase 1 (HO-1), a stress-induce...