Endothelin receptor antagonists: effects on extracellular matrix synthesis in primary cultures of skin fibroblasts from systemic sclerosis patients

• Main Authors: B. Villaggio (Author), B. Seriolo (Author), A. Sulli (Author), A. Parodio (Author), C. Ferrone (Author), R. Brizzolara (Author), P. Montagna (Author), S. Soldano (Author), M. Cutolo (Author)
• Format: Book
• Published: PAGEPress Publications, 2012-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Endothelin-1 (ET-1) seems to enhance the pro-fibrotic protein synthesis by skin fibroblasts and its effects are mediated by endothelin-A and B (ETA and ETB) receptors. This study aimed to investigate the effects of ETA and ETB receptor antagonists (ETARA-sitaxentan and ETA/BRA-bosentan) on type I co...