Metformin improves ovarian follicle dynamics by reducing theca cell proliferation and CYP-17 expression in an androgenized rat model

• Main Authors: Roberta Rassi Mahamed (Author), Carla Cristina Maganhin (Author), Gisela Rodrigues Silva Sasso (Author), Manuel de Jesus Simões (Author), Maria Candida Pinheiro Baracat (Author), Edmund Chada Baracat (Author), José Maria Soares- (Author)
• Format: Book
• Published: BMC, 2018-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Metformin influences insulin receptor signaling, which might interfere with the proliferation of ovarian follicular structures and steroidogenesis. We hypothesize that reductions in glucose and insulin levels might interfere with CYP-17 expression and histomorphological changes i...