Reprogramming the body weight set point by a reciprocal interaction of hypothalamic leptin sensitivity and Pomc gene expression reverts extreme obesity

• Asıl Yazarlar: Kavaljit H. Chhabra (Yazar), Jessica M. Adams (Yazar), Graham L. Jones (Yazar), Miho Yamashita (Yazar), Martin Schlapschy (Yazar), Arne Skerra (Yazar), Marcelo Rubinstein (Yazar), Malcolm J. Low (Yazar)
• Materyal Türü: Kitap
• Baskı/Yayın Bilgisi: Elsevier, 2016-10-01T00:00:00Z.
• Konular: article
• Online Erişim: Connect to this object online.

Objective: A major challenge for obesity treatment is the maintenance of reduced body weight. Diet-induced obese mice are resistant to achieving normoweight once the obesogenic conditions are reversed, in part because lowered circulating leptin leads to a reduction in metabolic rate and a rebound of...