Reprogramming the body weight set point by a reciprocal interaction of hypothalamic leptin sensitivity and Pomc gene expression reverts extreme obesity

• Main Authors: Kavaljit H. Chhabra (Author), Jessica M. Adams (Author), Graham L. Jones (Author), Miho Yamashita (Author), Martin Schlapschy (Author), Arne Skerra (Author), Marcelo Rubinstein (Author), Malcolm J. Low (Author)
• Format: Book
• Published: Elsevier, 2016-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: A major challenge for obesity treatment is the maintenance of reduced body weight. Diet-induced obese mice are resistant to achieving normoweight once the obesogenic conditions are reversed, in part because lowered circulating leptin leads to a reduction in metabolic rate and a rebound of...