miR-539-5p regulates Srebf1 transcription in the skeletal muscle of diabetic mice by targeting DNA methyltransferase 3b

• Main Authors: Devesh Kesharwani (Author), Amit Kumar (Author), Ashima Rizvi (Author), Malabika Datta (Author)
• Formato: Libro
• Publicado: Elsevier, 2022-09-01T00:00:00Z.
• Subjects: article
• Acceso en liña: Connect to this object online.

Aberrant DNA methylation is associated with diabetes, but the precise regulatory events that control the levels and activity of DNA methyltransferases (DNMTs) is not well understood. Here we show that miR-539-5p targets Dnmt3b and regulates its cellular levels. miR-539-5p and Dnmt3b show inverse pat...