Reducing neonatal Fc receptor binding enhances clearance and brain-to-blood ratio of TfR-delivered bispecific amyloid-β antibody

• Main Authors: Eva Schlein (Author), Ken G. Andersson (Author), Tiffany Dallas (Author), Stina Syvänen (Author), Dag Sehlin (Author)
• Formato: Libro
• Publicado: Taylor & Francis Group, 2024-12-01T00:00:00Z.
• Subjects: article
• Acceso en liña: Connect to this object online.

ABSTRACTRecent development of amyloid-β (Aβ)-targeted immunotherapies for Alzheimer's disease (AD) have highlighted the need for accurate diagnostic methods. Antibody-based positron emission tomography (PET) ligands are well suited for this purpose as they can be directed toward the same target...