Tbx1 represses Mef2c gene expression and is correlated with histone 3 deacetylation of the anterior heart field enhancer

• Main Authors: Luna Simona Pane (Author), Filomena Gabriella Fulcoli (Author), Andrea Cirino (Author), Alessandra Altomonte (Author), Rosa Ferrentino (Author), Marchesa Bilio (Author), Antonio Baldini (Author)
• Format: Book
• Published: The Company of Biologists, 2018-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The TBX1 gene is haploinsufficient in 22q11.2 deletion syndrome (22q11.2DS), and genetic evidence from human patients and mouse models points to a major role of this gene in the pathogenesis of this syndrome. Tbx1 can activate and repress transcription, and previous work has shown that one of its fu...