Genomics Analysis of Metabolic Pathways of Human Stem Cell-Derived Microglia-Like Cells and the Integrated Cortical Spheroids

• Main Authors: Julie Bejoy (Author), Xuegang Yuan (Author), Liqing Song (Author), Thien Hua (Author), Richard Jeske (Author), Sébastien Sart (Author), Qing-Xiang Amy Sang (Author), Yan Li (Author)
• Format: Book
• Published: Hindawi Limited, 2019-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Brain spheroids or organoids derived from human pluripotent stem cells (hiPSCs) are still not capable of completely recapitulating in vivo human brain tissue, and one of the limitations is lack of microglia. To add built-in immune function, coculture of the dorsal forebrain spheroids with isogenic m...