Matrix metalloproteinase 9 production by monocytes is enhanced by TNF and participates in the pathology of human cutaneous Leishmaniasis.

• Main Authors: Taís M Campos (Author), Sara T Passos (Author), Fernanda O Novais (Author), Daniel P Beiting (Author), Rúbia S Costa (Author), Adriano Queiroz (Author), David Mosser (Author), Phillip Scott (Author), Edgar M Carvalho (Author), Lucas P Carvalho (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2014-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

INTRODUCTION:Cutaneous leishmaniasis (CL) due to L.braziliensis infection is characterized by a strong inflammatory response with high levels of TNF and ulcer development. Less attention has been given to the role of mononuclear phagocytes to this process. Monocytes constitute a heterogeneous popula...