The Bradycardic Agent Ivabradine Acts as an Atypical Inhibitor of Voltage-Gated Sodium Channels

• Main Authors: Benjamin Hackl (Author), Peter Lukacs (Author), Janine Ebner (Author), Krisztina Pesti (Author), Nicholas Haechl (Author), Mátyás C Földi (Author), Elena Lilliu (Author), Klaus Schicker (Author), Helmut Kubista (Author), Anna Stary-Weinzinger (Author), Karlheinz Hilber (Author), Arpad Mike (Author), Hannes Todt (Author), Xaver Koenig (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background and purpose: Ivabradine is clinically administered to lower the heart rate, proposedly by inhibiting hyperpolarization-activated cyclic nucleotide-gated cation channels in the sinoatrial node. Recent evidence suggests that voltage-gated sodium channels (VGSC) are inhibited within the same...