Stimulation of Adenosine A2B Receptor Inhibits Endothelin-1-Induced Cardiac Fibroblast Proliferation and α-Smooth Muscle Actin Synthesis Through the cAMP/Epac/PI3K/Akt-Signaling Pathway

Stimulation of Adenosine A2B Receptor Inhibits Endothelin-1-Induced Cardiac Fibroblast Proliferation and α-Smooth Muscle Actin Synthesis Through the cAMP/Epac/PI3K/Akt-Signaling Pathway

Background and Purpose: Cardiac fibrosis is characterized by an increase in fibroblast proliferation, overproduction of extracellular matrix proteins, and the formation of myofibroblast that express α-smooth muscle actin (α-SMA). Endothelin-1 (ET-1) is involved in the pathogenesis of cardiac fibrosi...

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Main Authors: Sarawuth Phosri (Author), Ajaree Arieyawong (Author), Kwanchai Bunrukchai (Author), Warisara Parichatikanond (Author), Akiyuki Nishimura (Author), Motohiro Nishida (Author), Supachoke Mangmool (Author)
Format: Book
Published: Frontiers Media S.A., 2017-06-01T00:00:00Z.
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3rd Floor Main Library

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