Human immunoglobulin from transchromosomic bovines hyperimmunized with SARS-CoV-2 spike antigen efficiently neutralizes viral variants

• Main Authors: Zhuoming Liu (Author), Hua Wu (Author), Kristi A. Egland (Author), Theron C. Gilliland (Author), Matthew D. Dunn (Author), Thomas C. Luke (Author), Eddie J. Sullivan (Author), William B. Klimstra (Author), Christoph L. Bausch (Author), Sean P. J. Whelan (Author)
• Format: Book
• Published: Taylor & Francis Group, 2022-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants with amino-acid substitutions and deletions in spike protein (S) can reduce the effectiveness of monoclonal antibodies (mAbs) and may compromise immunity induced by vaccines. We report a polyclonal, fully human, anti-SARS-CoV-2 im...